Spawned of alchemy and blood, he was the last of a brutal, ancient line. Now he has just been reborn. Deep in a Texas cave, the military unearths a five-hundred-year-old corpse, its desiccated flesh teeming with mysterious DNA that can transform mortals into beings of unimaginable power. Captain Scott Boulder, leader of a Black Ops unit that has been endowed with these superhuman abilities, is among the first to benefit from the find. But when, with the help of a voodoo priestess, the creature is conjured to life, unleashing an ancient evil bent on reinstating its poisonous kind on earth, Scott knows he must return the monster to the grave. But this is no ordinary vampire. Once a brutal torturer in the Spanish Inquisition, it can bend the laws of science and magic in horrifying new ways. Powerless to fight this evil alone, Scott grudgingly seeks the aid of reclusive anthropologist Leah Maguire, an expert in the mystical rituals of the past. To keep humanity from entering a new Dark Age, Scott and Leah will battle unspeakable horrors and will sacrifice everything they hold dear–perhaps even their own humanity–to destroy the last vampire.

On the sultry streets of New Orleans, Captain Scott Boulder and Leah Maguire are about to begin a deadly mission. The traumatized, genetically altered subjects of a Department of Defense experiment gone wrong have escaped, among them Rachel Ackart, a beautiful, seductive, and powerful woman—who is now under the dangerous influence of Andre Espinoza de Madrid, a vampire of incomparable evil and power. While Predator drones circle above New Orleans, and the sound of Black Hawk helicopters rends the air, Scott and Leah must fight their growing attraction to each other as they pursue their quarry amid the haunted and the damned. But Rachel is one step ahead of them. Andre’s vampire agent will soon unleash the greatest terror of all.