Jess in on the hunt for yet another wanted man when he comes across a wanted poster on a woman by the name of Jane Lacey. She is wanted for the killing of Jethro Mercer. The reward money is being offered by Walt Mercer, a rich and ruthless businessman, and Jethro's father. What Walt Mercer doesn't know, is that Jethro raped Jane Lacey and was about to murder her to keep it quiet when she kills him in self-defense. Blind fate brings Jess and Jane together, where Jess learns that there was a witness to her rape and the killing of Jethro Mercer. When Jess hears the story about what happened, he sets off on a hunt for the only witness, who fled and is in hiding, afraid of what Walt Mercer might do to him. It starts out as a simple enough job; find Rubin Fisher and make him ride back to Defiancé, Texas, and tell Walt Mercer what really happened. But the job quickly turns out to be anything but simple. Mercer puts up twenty-five thousand dollars for anyone who brings him Jane Lacey alive. Jess takes Jane on his hunt for Rubin Fisher and it takes a deadly turn with every gunslinger and bounty hunter in Texas hunting Jane for the twenty-five thousand dollars Walt Mercer put on her head. Strange partnerships are formed and a lot of men start dying along the way, and Jess is determined that Jane Lacey won't be one of the ones going down.