John Burgoyne awakens from a Halloween party, with a hangover and a dead cell phone, on the first day of the End of Days. He's desperate, on the run, and fighting for his life. After a violent coup, the Father, the figurehead of the Holy Covenant and the commander of a new military order, pursues John through the post-apocalyptic wreckage of Cleveland, Ohio, in search of the hidden knowledge he believes John holds. Burgoyne escapes and aligns with the resistance until Father orchestrates a final showdown.

A band of revolutionaries fights for survival in the urban decay of Pittsburgh, Pennsylvania, thirty years after the First Cleansing brought an end to civilization. Their enigmatic and seasoned patriarch, John Burgoyne, protects the clan until a man on horseback delivers an ominous message. John decides to lead his tribe on a grueling march down the treacherous highway stretching from Pittsburgh to Cleveland, unaware of the forces aligning against them. When the clan faces a major decision on the road, John will be forced to do whatever is necessary to ensure their survival.