The event of the year begins here! When The Lone Gunmen discover Internet files from future, they learn that a plague will soon wipe out most of humanity. With Agents Mulder and Scully working one lead, the Gunmen must spring into action and investigate several urban legends: a group of ghost-hunters, mutant turtles that live in the sewers, shape-changing alien robots, and a vengeful spirit from beyond the grave!

The Conspiracy continues! The Lone Gunmen investigate their first lead, the Ghostbusters. Are they frauds and charlatans, bilking unwitting clients out of money? Or do they have special insight into the afterlife? And how are they connected to the plague that's poised to wipe out humanity?

The Lone Gunmen's trail of secrets leads them to evidence of extraterrestrial life—mechanical extraterrestrial life! Will OPTIMUS PRIME and his allies trust these human interlopers—and what secret conspiracy could involve CYBERTRON, anyway?!

Bernard is a decorated state policeman in love with his partner. But their romance is brutally cut short when both die following a high-speed pursuit and fiery car crash involving the Lone Gunmen. Bernard inexplicably awakens to find himself resurrected by an otherworldly crow and with only one thing on his mind: vengeance.

The event of the year concludes here! The Lone Gunmen have finished investigating several urban legends—a group of ghost-hunters, mutant turtles that live in the sewers, shape-changing alien robots, and a vengeful spirit from beyond the grave—after receiving Internet files from future that foretell a plague that wipes out most of humanity. Now it's a race against the clock as the Gunmen, with Agents Mulder and Scully, attempt to save the world!