Join the crew of the original Starship Enterprise in these all-new adventures near the end of their five-year mission. The Enterprise and her crew finally make it back to Federation space, but the Federation they find isn't quite the same as the one they had left behind! Kirk grapples with a very personal Klingon threat, even as the Enterprise begins its homecoming victory tour, and the Federation's upcoming presidential election is upended when Harry Mudd enters the race! All this against the backdrop of a sinister malaise threatening to rot the Federation from within. Terrible secrets are revealed, among them the origin of Gary Seven and the grand designs of the shadowy AEGIS organization. Can Kirk and the Enterprise crew excise this corruption, or will the five-year mission end in failure? Collects issues #13-19 of the ongoing series by writers Jackson Lanzing, Collin Kelly, Jody Houser, and Jim McCann with artists Angel Hernandez, Silvia Califano, and J.K. Woodward.

The five-year mission reaches its epic conclusion, where Kirk and the Enterprise crew will have their bonds tested, secrets revealed, and futures cast into doubt! First, Kirk meets his romantic match in fellow Starfleet captain Laura Rhone. But will she be the one, or the one that got away? Then, while investigating a mysterious structure on his home planet, Spock vanishes! Can Kirk, Bones, and company find where—or when—their friend has gone? And what does Spock's entanglement in Vulcan's past mean for its future? Finally, the showdown that's been building for the last year is here! Gary Seven and the shadowy AEGIS organization's scheme has stretched from the grand Tholian Assembly to the pestilential Harry Mudd. Now their ultimate plan comes to fruition, and only the crew of the U.S.S. Enterprise can hope to stop it! When the smoke clears, what will be left for our heroes? Collects issues #20–25 of the series.