A mysterious island. An ancient plague. The doctors will see you now... On break from med school, Annabel and her sister Jezebel embark on a sight-seeing cruise off the coast of Italy. But their idyllic getaway comes to a terrifying halt with the sudden appearance of a violent storm. A collision with a mysterious ghost ship sends their boat to the bottom of the ocean, and strands the sisters and other survivors on a desolate island. As Annabel tends to the survivors’ wounds, the storm forces them to seek shelter in the remains of an ancient medieval town. But they soon learn they are not alone. Bonfires choke the empty streets with smoke. Jezebel sees strange apparitions, visions she cannot explain. And when the abandoned town’s church bells toll, the island’s most terrifying secret of all is revealed... The Plague Doctors, malevolent spirits of medicine gone wrong, infest the town’s unholy grounds. Their touch brings death by horrible disease. Their red-robed minions stalk the night, snatching away ‘patients’ for their sinister masters. As the doctors’ insidious infection contaminates the survivors, paranoia takes hold. The group begins to turn on itself. Using only their wits, and Jezebel’s uncanny sixth sense, Annabel and her sister manage to survive the deadly ghosts’ first assault. But when the sun sets and the bonfires blaze, the Plague Doctors will return. And the two sisters are about to become their next patients…

A maze of death. A town gripped by fear. The Plague Doctors return with a new prescription for terror. After surviving a disaster at sea, Med student Annabel and her sister Jezebel were shipwrecked on a desolate island haunted by the Plague Doctors. These sinister ghosts have spread a supernatural infection through the island's inhabitants, and they intend to make the two sisters their next patients. Escaping the horrific Doctors’ ghost town, the two sisters flee to a nearby village, desperate to find a hospital and medical attention. But they soon discover the entire island is under the thrall of the vicious Plague Doctors. An attack by one of creature’s undead minions throws the small town into chaos. Annabel and her sister find themselves captured in a vast hedge maze growing wild on the island. Injured, terrified, and separated, the two sisters are hopelessly lost in the overgrown labyrinth. Every step they take could be their last. The maze is a trap, designed to contain the infected victims of the malevolent spirits. And the Plague Doctors are stalking them through every twist and turn, eager to treat these new patients with a terminal dose of pain and fear. Annabel and Jezebel must work together to solve the riddle of the maze, and escape the villager’s trap. Or else the Plague Doctors will claim two new souls for their unholy experiments.

Med student Annabel and her older sister Jezebel are trapped in a waking nightmare. After escaping from the deadly island haunted by the Plague Doctors, the two sisters and fellow survivor, Henry, manage to find salvation on a rickety old boat that promises to take them home. But once again, they encounter the spectral ship that sails the island’s waters, forcing them back to the rocky coast. As they flee the minions of the haunted Spanish Galleon, the old ship’s original manifest provides a clue to the Plague Doctor’s hideous origins. But before they can decipher its meaning, the evil Doctors return with a vengeance. Fighting to stay alive, the three survivors must solve the riddle of the Plague Doctors, and expose the lies and corruption that doomed the island to its supernatural curse. But as they follow the trail of death and horror, they uncover a terrifying new secret. The Plague Doctors are not the only spirits that haunt the island...